Amsterdam, The Netherlands, 1 July 2020 – Scenic Biotech BV (“Scenic”), a pioneer in the discovery of genetic modifiers to enable the development of disease modifying therapeutics for rare genetic disorders and other devastating illnesses, today announced that Dr C. A. Oscar Izeboud has been appointed as Chief Executive Officer (CEO). Former acting CEO and scientific co-founder Dr Sebastian Nijman takes on the role of Chief Scientific Officer (CSO).
Dr Izeboud brings over 20 years life science and finance industry experience to Scenic at a pivotal stage in the Company’s development as it expands the utility of its Cell-Seq high resolution genetics platform and transitions its early pipeline from discovery into development.

Prior to joining Scenic Dr Izeboud served as Managing Director at NIBC Bank N.V. in Amsterdam, where he led its corporate finance and capital markets team with a focus on innovation and growth companies. Previously, Dr Izeboud successfully developed the Life Sciences and Healthcare practice of Kempen & Co., a Dutch merchant bank. During his tenure at Kempen & Co. and NIBC Bank, Dr. Izeboud was instrumental in numerous public and private transactions in Europe and the USA. Prior to entering the banking industry, Dr. Izeboud served as the Director of Business Development at the biotechnology company, Crucell, which was later acquired by Johnson & Johnson in 2011. In addition to his CEO role, he serves on the Board of Directors at Luciole Medical. Dr Izeboud received his Ph.D. in immunopharmacology from the University of Utrecht in the Netherlands.

Dr Ulrich Grau, Chairman of the Board of Scenic Biotech, commented:
“On behalf of the board and management I am delighted to welcome Oscar as Scenic’s new CEO. With his extensive experience and impressive achievements, he complements and strengthens the outstanding scientific acumen of the Scenic team allowing the company to play a pioneering role in identifying genetic modifiers as novel drug targets. Using its proprietary Cell-Seq platform the Company is now poised to progress its portfolio of programs in immuno-oncology and rare inherited diseases.”

Welcoming Dr Izeboud to the team, Dr Sebastian Nijman co-founder and CSO of Scenic Biotech said:
“In the last three years Scenic has pioneered the genetic modifier space and is now gaining momentum on all fronts, including its lead QPCTL immuno-oncology program. Hence, the timing of bringing in Oscar could not be better. He has an outstanding track record in strategic leadership and building company value through his unique mix of financing and business development experience across the life science and healthcare sectors. We look forward to working with him.”

Dr Izeboud, CEO of Scenic Biotech commented: “Scenic it is one of the most exciting early stage biotech companies in Europe and I am excited to be taking on the CEO role at this pivotal time. Working at the forefront of identifying genetic modifiers as disease targets for drug intervention, Scenic has immense potential to develop breakthrough therapies for rare inherited diseases and cancer. I am impressed with what the team has achieved so far and look forward to driving Scenic’s further development.”

Scenic recently announced it had been awarded a €3.1 million Innovation Credit from the Dutch
Government, to support its lead CD47/QPCTL immuno-oncology program through preclinical
development towards human clinical studies.

About Scenic Biotech
Scenic Biotech is focused on identifying genetic modifiers, a completely new class of disease
targets, for drug intervention. Also known as disease suppressors, genetic modifiers are genes that
act to suppress or completely block the effect of a disease-causing mutated gene.
As a pioneer in the field, Scenic Biotech is building the largest proprietary data warehouse of
genetic modifiers and has already identified a number of novel genetic modifiers for over a dozen
inherited diseases. This approach is enabling the development of disease modifying therapeutics for
devastating diseases including inherited rare diseases and cancer.
Scenic Biotech is headquartered in Amsterdam, the Netherlands. The Company was founded in
2017 as a spin-out of the Netherlands Cancer Institute, and Oxford University, backed by a Dutch-
UK syndicate of Venture Capital investors that include BioGeneration Ventures, Inkef Capital, and
Oxford Sciences Innovation. It has received €3.1 M non-dilutive Innovation Credit funding from the
Dutch government RVO agency of the Ministry of Economic Affairs and Climate Policy.
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About Genetic Modifiers
Genetic modifiers or disease suppressors are genes that counteract the effect of a disease-causing
gene. They explain why some people with genetic mutations linked to severe disease end up having
only mild or no symptoms. Genetic modifiers therefore positively influence the severity of disease
and act as a ‘natural form of protection’. Genetic modifiers are a completely new class of
therapeutic/drug targets.

For Further information, please contact:
At the Company

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